apoptotic chromatin condensation inducer 1

Symbol

ACIN1 (may also be known as: None)

Organism

Human

Description

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Orthologs

SymbolSpecies
Acn Drosophila melanogaster
acin1b Danio rerio
Acin1 Mus musculus
Acin1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006200 ATP catabolic process biological_process
GO:0006915 apoptotic process biological_process
GO:0006921 cellular component disassembly involved in apoptosis biological_process
GO:0030218 erythrocyte differentiation biological_process
GO:0030263 apoptotic chromosome condensation biological_process
GO:0045657 positive regulation of monocyte differentiation biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0016607 nuclear speck cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003676 nucleic acid binding molecular_function
GO:0005515 protein binding molecular_function
GO:0016887 ATPase activity molecular_function
GO:0019899 enzyme binding molecular_function